National Academy of Sciences, Proceedings of the National Academy of Sciences, 29(118), 2021
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Significance Inflammatory bowel disease (IBD) is a chronic debilitating condition with limited treatment options. Recently, we found that telomerase reactivation can ameliorate intestinal inflammation in a mouse model of IBD through the regulation of the YAP1/pro-IL-18 axis. This study aims to validate the therapeutic potential of this axis genetically and with the use of small molecule activators and inhibitors in the intestinal epithelium of IBD patients.