Objective: To evaluate the effect of 10% cream of green coffee oil on skin Wounds in Wistar Rats. Materials and Methods: We used 36 Wistar Rats, randomly divided between 3 groups: Inert Group (I, n = 12), Wounds were cleaned and treated with cream without the active ingredient once a day; Green Coffee (CV, n = 12), Wounds were cleaned and treated with 10% green coffee cream once a day; Dexpanthenol (SD, n = 12), Wounds were cleaned and treated with 5% Dexpanthenol once a day. As lesions had been generated by 8mm drilling, the same have been treated topically every day. On the 3rd , 7th and 14th day after Surgery, four Animals / group were sacrificed, or a Fragment of skin around the Wound was collected and processed histologically. Results: Green coffee cream is a 10% stimulus in the Repair process, such as Wounds without signs of infection, and an increase in the number of mononuclear Cells and fibroblasts (p 0.05), good entanglement of collagen Fibers and less healing time presented to the other studied groups. Conclusion: 10% green coffee oil has Pharmacological potential in the healing of skin Wounds.