To date, roadmaps and policies for transitioning from fossil fuels to clean, renewable energy have been developed for nations, provinces, states, cities, and towns in order to address air pollution, global warming, and energy insecurity. However, neither roadmaps nor policies have been developed for large metropolitan areas (aggregations of towns and cities), including megacities (metropolitan areas with populations above 10 million). This study bridges that gap by developing roadmaps to transition 74 metropolitan areas worldwide, including 30 megacities, to 100% wind, water, and sunlight (WWS) energy and storage for all energy sectors by no later than 2050, with at least 80% by 2030. Among all metropolitan areas examined, the full transition may reduce 2050 annual energy costs by 61.1% (from $2.2 to $0.86 trillion/yr in 2013 USD) and social costs (energy plus air pollution plus climate costs) by 89.6% (from $8.3 to $0.86 trillion/yr). The large energy cost reduction is due to the 57.1% lower end-used energy requirements and the 9% lower cost per unit energy with WWS. The air pollution cost reduction of ~$2.6 (1.5–4.6) trillion/yr is due mostly to the saving of 408,000 (322,000–506,000) lives/yr with WWS. Global climate cost savings due to WWS are ~$3.5 (2.0–7.5) trillion/yr (2013 USD). The transition may also create ~1.4 million more long-term, full-time jobs than lost. Thus, moving to 100% clean, renewable energy and storage for all purposes in metropolitan areas can result in significant economic, health, climate, and job benefits.