Published in
American Association for the Advancement of Science, Science Translational Medicine, 612(13), 2021
DOI: 10.1126/scitranslmed.abf2750
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Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy
Journal article published in 2021 by
Arwa Kohela 
,
Sebastiaan J. van Kampen ,
Tara Moens,
Martijn Wehrens ,
Bas Molenaar,
Cornelis J. Boogerd ,
Jantine Monshouwer-Kloots,
Ilaria Perini,
Marie José Goumans ,
Anke M. Smits ,
J. Peter van Tintelen ,
Eva van Rooij
,
Sebastiaan J. van Kampen ,
Tara Moens,
Martijn Wehrens ,
Bas Molenaar,
Cornelis J. Boogerd ,
Jantine Monshouwer-Kloots,
Ilaria Perini,
Marie José Goumans ,
Anke M. Smits ,
J. Peter van Tintelen ,
Eva van Rooij
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Abstract
Modeling ACM using human-induced pluripotent stem cells shows that epicardial disruption of the desmosome drives cardiac fibro-fatty remodeling.