Published in
Royal Society of Chemistry, RSC Advances, 48(11), p. 30229-30236, 2021
DOI: 10.1039/d1ra05539a
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Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid
Journal article published in 2021 by
Mélanie Uguen 
,
Conghao Gai,
Lukas J. Sprenger,
Hang Liu,
Andrew G. Leach ,
Michael J. Waring
,
Conghao Gai,
Lukas J. Sprenger,
Hang Liu,
Andrew G. Leach ,
Michael J. Waring
This paper is made freely available by the publisher.
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Abstract
A new method for the synthesis of 4-oxo-2-butenoic acids is described by aldol condensation with methyl ketones. Substrate dependent conditions are rationalised mechanistically with quantum mechanically derived molecular orbital energies.