Published in
American Society of Hematology, Blood Advances, 18(4), p. 4550-4553, 2020
DOI: 10.1182/bloodadvances.2020001775
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Comparative genomics of CXCR4MUT and CXCR4WT single cells in Waldenström’s macroglobulinemia
Journal article published in 2020 by
Cristina Jiménez 
,
Lian Xu,
Nickolas Tsakmaklis,
Maria G. Demos,
Amanda Kofides,
Gloria G. Chan ,
Maria Luisa Guerrera,
Jiaji G. Chen,
Xia Liu,
Manit Munshi,
Christopher J. Patterson,
Guang Yang ,
Jorge J. Castillo ,
Steven P. Treon ,
Zachary R. Hunter
,
Lian Xu,
Nickolas Tsakmaklis,
Maria G. Demos,
Amanda Kofides,
Gloria G. Chan ,
Maria Luisa Guerrera,
Jiaji G. Chen,
Xia Liu,
Manit Munshi,
Christopher J. Patterson,
Guang Yang ,
Jorge J. Castillo ,
Steven P. Treon ,
Zachary R. Hunter
This paper is made freely available by the publisher.
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Abstract
Key Points Single-cell whole-genome amplification can be used to interrogate the genomic architecture of Waldenström’s macroglobulinemia. The mutational signature of CXCR4MUT cells may be associated with alterations in DNA repairing genes and tumor suppressors.