Published in
American Association for the Advancement of Science, Science Immunology, 51(5), 2020
DOI: 10.1126/sciimmunol.abb5590
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IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Journal article published in 2020 by
Heather M. Ren 
,
Elizabeth M. Kolawole ,
Mingqiang Ren ,
Ge Jin,
Colleen S. Netherby-Winslow ,
Quinn Wade ,
Shwetank ,
Ziaur S. M. Rahman,
Brian D. Evavold ,
Aron E. Lukacher
,
Elizabeth M. Kolawole ,
Mingqiang Ren ,
Ge Jin,
Colleen S. Netherby-Winslow ,
Quinn Wade ,
Shwetank ,
Ziaur S. M. Rahman,
Brian D. Evavold ,
Aron E. Lukacher
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Abstract
High-affinity CD4 T cells produce IL-21 to help CD8 T cells differentiate into tissue-resident memory cells in the brain.