ABSTRACT The Barbados gooseberry crop has agricultural potential, but little information is available regarding cropping practices. More information on weed interference in Barbados gooseberry will support growers to take weed management decisions. The objective of this work was to study initial growth and development of Barbados gooseberry under the interference of weeds. The experiment was conducted in a completely randomized design, with five treatments, composed of Barbados gooseberry in competition with four weed species: slender amaranth (Amaranthus viridis), hairy beggarticks (Bidens pilosa), Benghal dayflower (Commelina benghalensis), purple nutsedge (Cyperus rotundus), and a weed-free control, with six replicates. Weed competition led to a decrease in growth and development of Barbados gooseberry reflected in a reduction of up to 40% in yield and 23% in protein content. Additional work must be conducted evaluating these findings under field conditions, using different seedling production and planting techniques potentially affecting these results.