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American Association for the Advancement of Science, Science Translational Medicine, 610(13), 2021

DOI: 10.1126/scitranslmed.abc7804

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Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

Journal article published in 2021 by Christian Hotz ORCID, Timothy R. Wagenaar ORCID, Friederike Gieseke ORCID, Dinesh S. Bangari ORCID, Michelle Callahan ORCID, Hui Cao, Jan Diekmann, Mustafa Diken, Christian Grunwitz, Andy Hebert, Karl Hsu ORCID, Marie Bernardo, Katalin Karikó ORCID, Sebastian Kreiter ORCID, Andreas N. Kuhn and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Local immunotherapy with an mRNA mixture encoding four cytokines mobilizes a systemic antitumor response and promotes tumor eradication.