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American Society for Microbiology, Journal of Virology, 19(95), 2021

DOI: 10.1128/jvi.00566-21

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Mechanisms of Antiviral Cytotoxic CD4 T Cell Differentiation

Journal article published in 2021 by Cory J. Knudson, Maria Férez, Pedro Alves-Peixoto ORCID, Dan A. Erkes, Carolina R. Melo-Silva ORCID, Lingjuan Tang ORCID, Christopher M. Snyder ORCID, Luis J. Sigal ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

While it is well established that cytotoxic CD4 T cells (CD4-CTLs) directly contribute to viral clearance, it remains unclear how CD4-CTL are induced. We now show that CD4-CTLs require sustained antigen presentation and are induced by CD11c-expressing antigen-presenting cells.