Abstract Objectives To investigate the association of pericoronary adipose tissue mean attenuation (PCAT_MA) with coronary artery disease (CAD) characteristics on coronary computed tomography angiography (CCTA). Methods We retrospectively investigated 165 symptomatic patients who underwent third-generation dual-source CCTA at 70kVp: 93 with and 72 without CAD (204 arteries with plaque, 291 without plaque). CCTA was evaluated for presence and characteristics of CAD per artery. PCAT_MA was measured proximally and across the most severe stenosis. Patient-level, proximal PCAT_MA was defined as the mean of the proximal PCAT_MA of the three main coronary arteries. Analyses were performed on patient and vessel level. Results Mean proximal PCAT_MA was −96.2 ± 7.1 HU and −95.6 ± 7.8HU for patients with and without CAD (p = 0.644). In arteries with plaque, proximal and lesion-specific PCAT_MA was similar (−96.1 ± 9.6 HU, −95.9 ± 11.2 HU, p = 0.608). Lesion-specific PCAT_MA of arteries with plaque (−94.7 HU) differed from proximal PCAT_MA of arteries without plaque (−97.2 HU, p = 0.015). Minimal stenosis showed higher lesion-specific PCAT_MA (−94.0 HU) than severe stenosis (−98.5 HU, p = 0.030). Lesion-specific PCAT_MA of non-calcified, mixed, and calcified plaque was −96.5 HU, −94.6 HU, and −89.9 HU (p = 0.004). Vessel-based total plaque, lipid-rich necrotic core, and calcified plaque burden showed a very weak to moderate correlation with proximal PCAT_MA. Conclusions Lesion-specific PCAT_MA was higher in arteries with plaque than proximal PCAT_MA in arteries without plaque. Lesion-specific PCAT_MA was higher in non-calcified and mixed plaques compared to calcified plaques, and in minimal stenosis compared to severe; proximal PCAT_MA did not show these relationships. This suggests that lesion-specific PCAT_MA is related to plaque development and vulnerability. Key Points • In symptomatic patients undergoing CCTA at 70 kVp, PCAT_MAwas higher in coronary arteries with plaque than those without plaque. • PCAT_MAwas higher for non-calcified and mixed plaques compared to calcified plaques, and for minimal stenosis compared to severe stenosis. • In contrast to PCAT_MAmeasurement of the proximal vessels, lesion-specific PCAT_MAshowed clear relationships with plaque presence and stenosis degree.