Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an infectious disease where symptoms can be mild, requiring no treatment or severe, requiring hospital admission for hemodynamic support and mechanical ventilation. Given the affinity of SARS-CoV-2 to angiotensin-converting enzyme 2 (ACE2) receptors, the heart is a highly susceptible target to its associated damages. Knowledge about SARS-CoV-2 modes of transmission and their impact on the cardiovascular system is paramount for emergency department (ED) nurses to protect themselves and competently care for their patients. The authors of this manuscript aim to provide a clinical overview of the impact of SARS-CoV-2 on the cardiovascular system based on the latest scientific evidence. A profound understanding of SARS-CoV-2 and its related consequences has the potential to minimize its associated mortality and morbidity.