Inhibiting Type VI Secretion System Activity with a Biomimetic Peptide Designed To Target the Baseplate Wedge Complex
Journal article published in 2021 by
Y. Cherrak,
I. Filella-Merce,
V. Schmidt,
D. Byrne,
V. Sgoluppi,
R. Chaiaheloudjou,
S. Betzi 
,
X. Morelli,
M. Nilges,
R. Pellarin,
E. Durand
,
X. Morelli,
M. Nilges,
R. Pellarin,
E. Durand
This paper is made freely available by the publisher.
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Abstract
New therapeutic options are urgently needed to fight drug-resistant and life-threatening infections. In contrast to antibiotics that inhibit the growth pathways of bacteria, the antivirulence strategy is a promising approach to disarm pathogens by interfering with bacterial virulence factors without exerting evolutionary pressure.