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American Association for the Advancement of Science, Science, 6558(373), 2021

DOI: 10.1126/science.abg4696

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Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells

Journal article published in 2021 by Ioannis Sarropoulos ORCID, Mari Sepp ORCID, Robert Frömel ORCID, Kevin Leiss ORCID, Nils Trost ORCID, Evgeny Leushkin, Konstantin Okonechnikov ORCID, Piyush Joshi ORCID, Peter Giere ORCID, Lena M. Kutscher ORCID, Margarida Cardoso-Moreira ORCID, Stefan M. Pfister ORCID, Henrik Kaessmann ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The cerebellum reveals its genetic programs Gene-regulatory networks govern the development of organs. Sarropoulos et al . analyzed mouse cerebellar development in the context of gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility in about 90,000 cells revealed diversity in progenitor cells and genetic programs guiding cellular differentiation. The footsteps of evolution were apparent in varying constraints on different cell types. —PJH