Objective: Our objective is to provide a descriptive analysis of the quality of life among a large sample of health professionals in the early days of the pandemic. Method: We surveyed in the first months of the pandemics with the logistical support of the Health ministry in Brazil reaching more than 200,000 varied health professionals, with quality-of-life data, assessed using the WHOQOL-BREF, available to 97,379. We segregated the professionals by their reported field of work. Results: The different professions report a diverse quality of life, suggesting a more heterogeneous pattern of impairment. The social relations domain of quality of life was the most affected in or sample. Conclusion: Knowing the target population and the features related to worsening of quality of life might help to prepare the professionals for what they must face and to improve mental health in this population.