Published in
American Society for Microbiology, Journal of Virology, 14(95), 2021
DOI: 10.1128/jvi.00663-21
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Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome
Journal article published in 2021 by
Valeria Lulla 
,
Michal P. Wandel ,
Katarzyna J. Bandyra ,
Rachel Ulferts,
Mary Wu,
Tom Dendooven ,
Xiaofei Yang,
Nicole Doyle ,
Stephanie Oerum ,
Rupert Beale ,
Sara M. O’Rourke,
Felix Randow,
Helena J. Maier ,
William Scott,
Yiliang Ding
and other authors.
,
Michal P. Wandel ,
Katarzyna J. Bandyra ,
Rachel Ulferts,
Mary Wu,
Tom Dendooven ,
Xiaofei Yang,
Nicole Doyle ,
Stephanie Oerum ,
Rupert Beale ,
Sara M. O’Rourke,
Felix Randow,
Helena J. Maier ,
William Scott,
Yiliang Ding
and other authors.
This paper is made freely available by the publisher.
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Abstract
The highly conserved stem-loop 2 motif (s2m) is found in the genomes of many RNA viruses, including SARS-CoV-2. Our findings indicate that the s2m element can be targeted by antisense oligonucleotides. The antiviral potential of this conserved element represents a promising start for further research into targeting conserved elements in RNA viruses.