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European Centre for Disease Prevention and Control, Eurosurveillance, 11(26), 2021

DOI: 10.2807/1560-7917.es.2021.26.11.2100256

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Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February

Journal article published in 2021 by Daniel J. Grint ORCID, Grint Dj, Kevin Wing ORCID, Elizabeth Williamson, Helen I. McDonald ORCID, Krishnan Bhaskaran ORCID, David Evans, Stephen Jw Evans, Alex J. Walker, McDonald Hi, George Hickman, Emily Nightingale, Anna Schultze, Christopher T. Rentsch, Chris Bates ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34–2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.