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Future Medicine, Personalized Medicine, 3(18), p. 255-267, 2021

DOI: 10.2217/pme-2019-0141

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PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Journal article published in 2021 by Alessio Mosca ORCID, Antonio Del Casale ORCID, Marina Borro ORCID, Giovanna Gentile ORCID, Leda Marina Pomes, Alessio Padovano, Federica Fiaschè, Vito Pinzone, Chiara Rapinesi, Teodolinda Zoppi, Roberto Brugnoli, Gabriele Sani ORCID, Georgios Demetrios Kotzalidis ORCID, Paolo Girardi ORCID, Stefano Ferracuti ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.