Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.

Zhai, H.; Young, R.; Wu, Yin; Waddington, R.; Wilcox, M.; Wallen, J. E.; Veeriah, Selvaraju; Ward, Sophia; Lowe, H. L.; Ensell, L.; Spanswick,; López, Saioa; Karamani, A.; Moore, D.; Biswas, D.; Razaq, M.; Nicod, J.; Beck, S.; Lim, Emilia L.; Naceur-Lombardelli, C.; Akther,; Kannu, N.; Manzano, E.; Puttick, C.; Enfield, K.; Colliver, E.; Campbell, B.; El, Lim; Bola, S. K.; Ghorani, E.; De Massy, M. R.; Hoxha, E.; Hatipoglu, E.; Ogwuru, S.; Chain, B.; Abbosh, Christopher; Lester, J.; Morgan, F.; Rosenthal, Rachel; Kornaszewska, M.; Attanoos, R.; Adams, H.; Horswell, Stuart; Davies, H.; Fennell, D.; Le Quesne, J.; Escudero, Mickael; Nakas, A.; Rathinam, S.; Monteiro, W.; Stewart, Aengus; Marshall, H.; Nelson, L.; Ryanna, K.; Dawson, A.; Tuffail, M.; Goldman, Jacki; Bajaj, A.; Haase, Kerstin; Brozik, J.; Lovett, M. R.; Shaw, J. A.; Riley, J.; Skrzypski, Marcin; Watkins, Thomas B. K.; Primrose, L.; Martinson, L.; Carey, N.; Hynds, Robert E.; Anand, G.; Khan, S.; Mourikis, Thanos P.; Price, G.; Georgiou, Andy; Nicolson, M.; Huebner, Ariana; Kerr, K.; Palmer, S.; Sunderland, Mariana Werner; Remmen, H.; Miller, J.; Buchan, K.; Reading, James; Chetty, M.; Gomersall, L.; Lock, S.; Quezada, Sergio; Gilbert, K.; Naidu, B.; Langman, G.; Dietzen, Michelle; Peggs, Karl; Robinson, A.; Bancroft, H.; Kerr, A.; Marafioti, Teresa; Kadiri, S.; Wilson, Gareth A.; Ferris, C.; Middleton, G.; Djearaman, M.; Patel, A.; Hartley, John A.; Summers, Y.; Califano, R.; Taylor, P.; Stone, Richard Kevin; Shah, R.; Krysiak, P.; Rammohan, K.; Denner, Tamara; Dewhurst, Sally M.; Fontaine, E.; Booton, R.; Evison, M.; Nye, Emma; Crosbie, P.; Moss, S.; Novasio, J.; Joseph, L.; Bishop, P.; Chaturvedi, A.; Doran, H.; Boeing, Stefan; Tp, Mourikis; Granato, F.; Joshi,; Birkbak, Nicolai J.; Leek, A.; Greco, Maria; Harrison, P.; Moore, K.; Al-Bakir, Maise; Blackhall, F.; Rogan, J.; Smith, E.; Baker, K.; Litchfield, Kevin; Carter, M.; Priest, L.; Krebs, M. G.; Gorman, Pat; Rowan, Andrew; Lindsay, C. R.; Gomes, F.; Tbk, Watkins; Montero, A.; Dive, C.; Brady, G.; Jamal-Hanjani, Mariam; Rothwell, D. G.; Chemi, F.; Tugwood, J.; Pierce, J.; Lawrence, D.; Consortium, TRACERx; Hayward, M.; Panagiotopoulos, N.; George, R.; Patrini, D.; Falzon, M.; Borg, E.; Khiroya, R.; Hiley, C.; Taylor, M.; Choudhary, J.; Shaw, P.; Janes, S. M.; Forster, M.; Ahmad, T.; Lee, S. M.; Herrero, J.; Carnell, D.; Mendes, R.; George, J.; Navani, N.; Papadatos-Pastos, D.; Scarci, M.; Salgado, R.; Bertoja, E.; Stephens, R. C. M.; Hoogenboom, E. M.; Holding, J. W.; Bandula, S.; Sm, Dewhurst; Aerts, H.; Schwarz, R.; Swanton, Charles; Szallasi, Z.; Csabai, I.; Diossy, M.; MacKenzie, M.; Hackshaw, A.; Ngai, Y.; Sharp, A.; Rodrigues, C.; Pressey, O.; Smith, S.; Gower, N.; Dhanda, H.; Ottensmeier, C.; Chee, S.; Johnson, B.; Alzetani, A.; Nj, Birkbak; Shaw, E.; De Sousa, P.; Jordan, S.; Rice, A.; Ahmed, Asia; Raubenheimer, H.; Bhayani, H.; Van Loo, Peter; Hamilton, M.; Ambrose, L.; Devaraj, A.; Chavan, H.; Begum, S.; Mani, A.; Kaniu, D.; Malima, M.; Booth, S.; Nicholson, A. G.; Ga, Wilson; Fernandes, N.; Shah, P.; Lau, K.; Sheaff, M.; Schmid, P.; Conibear, J.; Ezhil,; Danson, S.; Bury, J.; Edwards, J.; Hill, J.; Matthews, S.; Kitsanta, Y.; Rao, J.; Tenconi, S.; Socci, L.; Suvarna, K.; Kibutu, F.; Fisher, P.; Barker, J.; Prakash, Vineet; Shackcloth, M.; Gosney, J.; Feeney, S.; Asante-Siaw, J.; McGranahan, Nicholas; Light, T.; Horey, T.; Russell, P.; Blyth, K. G.; Dick, C.; Kidd, A.; Kirk, A.; Asif, M.; Butler, J.; Bilanca, R.; Kostoulas, N.

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Nature Research, Nature Genetics, 3(52), p. 283-293, 2020

DOI: 10.1038/s41588-020-0584-7

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Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.

Journal article published in 2020 by H. Zhai, R. Young, Yin Wu, R. Waddington, M. Wilcox, J. E. Wallen, Selvaraju Veeriah, Sophia Ward, H. L. Lowe, L. Ensell, Spanswick, Saioa López, A. Karamani, D. Moore, D. Biswas and other authors.

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Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution.