Published in
American Association for the Advancement of Science, Science Translational Medicine, 587(13), 2021
DOI: 10.1126/scitranslmed.aba6322
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Clearance of pegylated interferon by Kupffer cells limits NK cell activation and therapy response of patients with HBV infection
Journal article published in 2021 by
Akira Nishio 
,
Fabian J. Bolte,
Kazuyo Takeda,
Nana Park,
Zu-Xi Yu,
Heiyoung Park,
Kristin Valdez ,
Marc G. Ghany ,
Barbara Rehermann
,
Fabian J. Bolte,
Kazuyo Takeda,
Nana Park,
Zu-Xi Yu,
Heiyoung Park,
Kristin Valdez ,
Marc G. Ghany ,
Barbara Rehermann
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Abstract
The innate immune response of patients with HBV infection to pegylated interferon therapy is reduced by sequestration of PEG–IFN-α/anti-PEG complexes.