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National Academy of Sciences, Proceedings of the National Academy of Sciences, 11(118), 2021

DOI: 10.1073/pnas.2020152118

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Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors

Journal article published in 2021 by Valeska Helfinger ORCID, Florian Freiherr von Gall, Nina Henke, Michael M. Kunze, Tobias Schmid, Flavia Rezende ORCID, Juliana Heidler, Ilka Wittig, Heinfried H. Radeke ORCID, Viola Marschall, Karen Anderson ORCID, Ajay M. Shah, Simone Fulda, Bernhard Brüne ORCID, Ralf P. Brandes ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Significance The stereotype of ROS produced by NADPH oxidases as cause of malignant diseases persists in a generalized manner. In fact, high levels of ROS formation could be harmful in the context of a disease process. This study demonstrates that loss of the NADPH oxidase Nox4, as a constitutive source of ROS, promotes cancerogen-induced formation of solid tumors. Accordingly, a certain tonic, constitutive low level of Nox4-derived hydrogen peroxide appears to reduce the risk of cancerogen-induced tumor formation.