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American Association for the Advancement of Science, Science Advances, 8(7), 2021

DOI: 10.1126/sciadv.abe5496

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Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement

Journal article published in 2021 by Evan A. Boyle ORCID, Winston R. Becker ORCID, Hua B. Bai ORCID, Janice S. Chen ORCID, Jennifer A. Doudna ORCID, William J. Greenleaf ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A massive new resource of diverse Cas9 binding and cleavage events establishes new rules for effective CRISPR targeting.