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American Society for Microbiology, Journal of Clinical Microbiology, 5(59), 2021

DOI: 10.1128/jcm.02890-20

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Assessment of S1, S2 and NCP-specific IgM, IgA, and IgG antibody kinetics in acute SARS-CoV-2 infection by a microarray and twelve other immunoassays

Journal article published in 2021 by Georg Semmler ORCID, Marianna Theresia Traugott, Marianne Graninger, Wolfgang Hoepler, Tamara Seitz, Hasan Kelani, Mario Karolyi ORCID, Erich Pawelka, Sara Aragón de La Cruz, Elisabeth Puchhammer-Stöckl ORCID, Stephan Walter Aberle, Karin Stiasny ORCID, Alexander Zoufaly, Judith Helene Aberle, Lukas Weseslindtner ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In this study, we comprehensively analyzed multispecific antibody kinetics of different immunoglobulins in hospitalized patients with acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Three hundred fifty-four blood samples longitudinally obtained from 81 IgG-seroconverting progressed coronavirus disease 2019 (CoVID-19) patients were quantified for spike 1 (S1), S2, and nucleocapsid protein (NCP)-specific IgM, IgA, IgG, and total Ig antibodies using a microarray, 11 different enzyme-linked immunosorbent assays (ELISAs)/chemiluminescence immunoassays (CLIAs), and 1 rapid test by seven manufacturers.