Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Zhang, Ziyang; Rezelj, Veronica V.; Hiatt, Joseph; Gordon, David E.; Ulferts, Svenja; Obernier, Kirsten; Bouhaddou, Mehdi; Weckstein, Andrew R.; Jureka, Alexander S.; Owens, Tristan W.; Guo, Jeffrey Z.; Pourmal, Sergei; Zhou, Yuan; Titus, Erron W.; Braberg, Hannes; Kaake, Robyn M.; Zhang, Z.; Soucheray, Margaret; Zhou, Y.; Tummino, Tia A.; McGregor, Michael; O’Meara, Matthew J.; Rojc, Ajda; Batra, Jyoti; Gupta, Meghna; Cakir, Zeynep; O'Meara, Matthew J.; Jang, Gwendolyn; Xu, Jiewei; Swaney, Danielle L.; Foussard, Helene; Ummadi, Manisha; Kuchenov, Dmitry; Cakir, Merve; Tutuncuoglu, Beril; Huttenhain, Ruth; Rathore, Ujjwal; Eckhardt, Manon; Fabius, Jacqueline M.; Pulido, Ernst H.; Naing, Zun Zar Chi; Shi, Ying; Vv, Rezelj; Modak, Maya; Haas, Paige; Petsalaki, Eirini; Haas, Kelsey M.; Vallet, Thomas; Memon, Danish; Dunham, Alistair; Silvas, Jesus A.; Marrero, Miguel Correa; Koh, Cassandra; Liu, Yanxin; Campbell, Melody G.; Barrio-Hernandez, Inigo; Puchades, Cristina; Moritz, Michelle; Diallo, Amy; Young, Iris D.; Smith, Amber M.; Burke, David; Dickinson, Miles Sasha; Nguyen, Henry C.; Schulze-Gahmen, Ursula; Diwanji, Devan; Rizo, Alexandrea N.; Azumaya, Caleigh M.; Herrera, Nadia; Nowotny, Carlos; Billesbolle, Christian; Sun, Ming; Hoppe, Nick; Merz, Gregory E.; Brilot, Axel F.; Kratochvil, Huong T.; De, Gordon; Chio, Un Seng; Li, Yen-Li; Zhao, Jianhua; Li, Junrui; Chen, Jen; Chio, Cynthia M.; Deshpande, Ishan; Doan, Loan; Nguyen, Phuong; Faust, Bryan; Asarnow, Daniel; Flores, Sebastian; Biel, Justin; Jin, Mingliang; Moss, Frank R.; Kim, Kate; Safari, Maliheh; Bowen, Alisa; Paulino, Joana; Zhang, Yang; Wang, Feng; Lam, Victor L.; Braxton, Julian R.; Sangwan, Smriti; Whitis, Natalie; Thomas, Paul V.; Li, Fei; Thwin, Aye C.; Schaefer, Kaitlin; Pawar, Komal Ishwar; Yu, Zanlin; Pospiech, Thomas H.; Trenker, Raphael; Peters, Jessica K.; Liu, Xi; Zhang, Kaihua; Lo, Megan; Lopez, Kyle E.; Melo, Arthur A.; Tse, Eric; Li, Yang L.; Tsui, Tsz Kin Martin; Zhou, Fengbo; Williams, Daniel M.; Saltzberg, Daniel; White, Kris M.; Shun-Shion, Amber S.; Li, Y.; Rosales, Romel; Wu, David; Hodder, Anthony J.; Patel, Arvind H.; Vallejo-Gracia, Albert; Rihn, Suzannah; Miorin, Lisa; Kehrer, Thomas; Simoneau, Camille R.; Weigang, Sebastian; Roth, Theodore L.; Khalid, Mir M.; Li, Y.-L.; Fozouni, Parinaz; Lind, Abigail L.; Moreno, Elena; Weston, Stuart; Park, Jisoo; Karim, Mohd Anisul; Ghoussaini, Maya; Dunham, Ian; Chazal, Maxime; Wilkinson, Stuart G.; Logue, James; McGrath, Marisa; Berardi, Francesco; Reid, Elaine; Tw, Owens; Haupt, Robert; Elliott, Matthew; Raggett, Samantha; Dorward, Mark; Toth, Rachel; Johnson, Clare; Brown, Fiona; Geyer, Anna; Rm, Kaake; Giesel, Daniel M.; Burness, Kerry A.; Hastie, C. James; Leech, Hannah; Oki, Jennifer; James Hastie, C.; Goodman, Nicola; Keough, Kathleen C.; Pollard, Katherine S.; Sali, Andrej; Baillie, Carla; Klesh, Reyna J.; Hemphill, Kafi R.; Carlson-Stevermer, Jared; Holden, Kevin; Southworth, Daniel R.; Maures, Travis; Stroud, Robert M.; Cheng, Yifan; Fraser, James S.; Frost, Adam; Agard, David A.; Jura, Natalia; Trinidad, Donovan; Kortemme, Tanja; Shoichet, Brian; Manglik, Aashish; Ott, Melanie; Shokat, Kevan M.; Palmarini, Massimo; Davies, Paul; Jz, Guo; Frieman, Matthew B.; Alessi, Dario R.; Wirthlin, Morgan; Ideker, Trey; Rassen, Jeremy A.; Zhao, Huabin; Jouvenet, Nolwenn; Verba, Kliment A.; Abate, Carmen; Kochs, Georg; Rosenberg, Oren S.; Painter, Corrie A.; Garcia-Sastre, Adolfo; Wallerman, Ola; Vignuzzi, Marco; Peden, Andrew A.; Persky, Nicole S.; Grosse, Robert; Swofford, Ross; Ryderq, Oliver A.; Basler, Christopher F.; Billesbølle, Christian; Pfenning, Andreas R.; Krogan, Nevan J.; Beltrao, Pedro; Nj, Krogan; Teeling, Emma C.; Ray, David A.; Power, Sarahjane; Nweeia, Martin T.; As, Jureka; Damas, Joana; Hughes, Graham M.; Corbo, Marco; Kirilenko, Bodgan; Hiller, Michael; Koepfli, Klaus-Peter; Kaplow, Irene; Genereux, Diane P.; Meadows, Jennifer; Dong, Michael; Li, Shirley Xue; Marinescu, Vikki; Lindblad-Toh, Kerstin; Ar, Weckstein; Chauhan, Gaurav; Karlsson, Elinor K.; Lewin, Harris A.

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David Gordon
Zhang et al., 2020

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American Association for the Advancement of Science, Science, 6521(370), 2020

DOI: 10.1126/science.abe9403

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@article{Zhang2020,
  abstract = {How lethal coronaviruses engage hostsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordonet al.mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.Science, this issue p.eabe9403},
  author = {Zhang, Ziyang and Rezelj, Veronica V. and Hiatt, Joseph and Gordon, David E. and Ulferts, Svenja and Obernier, Kirsten and Bouhaddou, Mehdi and Weckstein, Andrew R. and Jureka, Alexander S. and Owens, Tristan W. and Guo, Jeffrey Z. and Pourmal, Sergei and Zhou, Yuan and Titus, Erron W. and Braberg, Hannes and Kaake, Robyn M. and Zhang, Z. and Soucheray, Margaret and Zhou, Y. and Tummino, Tia A. and McGregor, Michael and O’Meara, Matthew J. and Rojc, Ajda and Batra, Jyoti and Gupta, Meghna and Cakir, Zeynep and O'Meara, Matthew J. and Jang, Gwendolyn and Xu, Jiewei and Swaney, Danielle L. and Foussard, Helene and Ummadi, Manisha and Kuchenov, Dmitry and Cakir, Merve and Tutuncuoglu, Beril and Huttenhain, Ruth and Rathore, Ujjwal and Eckhardt, Manon and Fabius, Jacqueline M. and Pulido, Ernst H. and Naing, Zun Zar Chi and Shi, Ying and Vv, Rezelj and Modak, Maya and Haas, Paige and Petsalaki, Eirini and Haas, Kelsey M. and Vallet, Thomas and Memon, Danish and Dunham, Alistair and Silvas, Jesus A. and Marrero, Miguel Correa and Koh, Cassandra and Liu, Yanxin and Campbell, Melody G. and Barrio-Hernandez, Inigo and Puchades, Cristina and Moritz, Michelle and Diallo, Amy and Young, Iris D. and Smith, Amber M. and Burke, David and Dickinson, Miles Sasha and Nguyen, Henry C. and Schulze-Gahmen, Ursula and Diwanji, Devan and Rizo, Alexandrea N. and Azumaya, Caleigh M. and Herrera, Nadia and Nowotny, Carlos and Billesbolle, Christian and Sun, Ming and Hoppe, Nick and Merz, Gregory E. and Brilot, Axel F. and Kratochvil, Huong T. and De, Gordon and Chio, Un Seng and Li, Yen-Li and Zhao, Jianhua and Li, Junrui and Chen, Jen and Chio, Cynthia M. and Deshpande, Ishan and Doan, Loan and Nguyen, Phuong and Faust, Bryan and Asarnow, Daniel and Flores, Sebastian and Biel, Justin and Jin, Mingliang and Moss, Frank R. and Kim, Kate and Safari, Maliheh and Bowen, Alisa and Paulino, Joana and Zhang, Yang and Wang, Feng and Lam, Victor L. and Braxton, Julian R. and Sangwan, Smriti and Whitis, Natalie and Thomas, Paul V. and Li, Fei and Thwin, Aye C. and Schaefer, Kaitlin and Pawar, Komal Ishwar and Yu, Zanlin and Pospiech, Thomas H. and Trenker, Raphael and Peters, Jessica K. and Liu, Xi and Zhang, Kaihua and Lo, Megan and Lopez, Kyle E. and Melo, Arthur A. and Tse, Eric and Li, Yang L. and Tsui, Tsz Kin Martin and Zhou, Fengbo and Williams, Daniel M. and Saltzberg, Daniel and White, Kris M. and Shun-Shion, Amber S. and Li, Y. and Rosales, Romel and Wu, David and Hodder, Anthony J. and Patel, Arvind H. and Vallejo-Gracia, Albert and Rihn, Suzannah and Miorin, Lisa and Kehrer, Thomas and Simoneau, Camille R. and Weigang, Sebastian and Roth, Theodore L. and Khalid, Mir M. and Li, Y.-L. and Fozouni, Parinaz and Lind, Abigail L. and Moreno, Elena and Weston, Stuart and Park, Jisoo and Karim, Mohd Anisul and Ghoussaini, Maya and Dunham, Ian and Chazal, Maxime and Wilkinson, Stuart G. and Logue, James and McGrath, Marisa and Berardi, Francesco and Reid, Elaine and Tw, Owens and Haupt, Robert and Elliott, Matthew and Raggett, Samantha and Dorward, Mark and Toth, Rachel and Johnson, Clare and Brown, Fiona and Geyer, Anna and Rm, Kaake and Giesel, Daniel M. and Burness, Kerry A. and Hastie, C. James and Leech, Hannah and Oki, Jennifer and James Hastie, C. and Goodman, Nicola and Keough, Kathleen C. and Pollard, Katherine S. and Sali, Andrej and Baillie, Carla and Klesh, Reyna J. and Hemphill, Kafi R. and Carlson-Stevermer, Jared and Holden, Kevin and Southworth, Daniel R. and Maures, Travis and Stroud, Robert M. and Cheng, Yifan and Fraser, James S. and Frost, Adam and Agard, David A. and Jura, Natalia and Trinidad, Donovan and Kortemme, Tanja and Shoichet, Brian and Manglik, Aashish and Ott, Melanie and Shokat, Kevan M. and Palmarini, Massimo and Davies, Paul and Jz, Guo and Frieman, Matthew B. and Alessi, Dario R. and Wirthlin, Morgan and Ideker, Trey and Rassen, Jeremy A. and Zhao, Huabin and Jouvenet, Nolwenn and Verba, Kliment A. and Abate, Carmen and Kochs, Georg and Rosenberg, Oren S. and Painter, Corrie A. and Garcia-Sastre, Adolfo and Wallerman, Ola and Vignuzzi, Marco and Peden, Andrew A. and Persky, Nicole S. and Grosse, Robert and Swofford, Ross and Ryderq, Oliver A. and Basler, Christopher F. and Billesbølle, Christian and Pfenning, Andreas R. and Krogan, Nevan J. and Beltrao, Pedro and Nj, Krogan and Teeling, Emma C. and Ray, David A. and Power, Sarahjane and Nweeia, Martin T. and As, Jureka and Damas, Joana and Hughes, Graham M. and Corbo, Marco and Kirilenko, Bodgan and Hiller, Michael and Koepfli, Klaus-Peter and Kaplow, Irene and Genereux, Diane P. and Meadows, Jennifer and Dong, Michael and Li, Shirley Xue and Marinescu, Vikki and Lindblad-Toh, Kerstin and Ar, Weckstein and Chauhan, Gaurav and Karlsson, Elinor K. and Lewin, Harris A.},
  doi = {10.1126/science.abe9403},
  journal = {Science},
  month = {oct},
  title = {Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.},
  url = {https://oadoi.org/10.1126/science.abe9403},
  volume = {370},
  year = {2020}
}

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Journal article published in 2020 by Ziyang Zhang, Veronica V. Rezelj, Joseph Hiatt, David E. Gordon

, Svenja Ulferts, Kirsten Obernier, Mehdi Bouhaddou, Andrew R. Weckstein, Alexander S. Jureka, Tristan W. Owens, Jeffrey Z. Guo, Sergei Pourmal, Yuan Zhou, Erron W. Titus, Hannes Braberg and other authors. Ziyang Zhang, Veronica V. Rezelj, Joseph Hiatt, David E. Gordon

, Svenja Ulferts, Kirsten Obernier, Mehdi Bouhaddou, Andrew R. Weckstein, Alexander S. Jureka, Tristan W. Owens, Jeffrey Z. Guo, Sergei Pourmal, Yuan Zhou, Erron W. Titus, Hannes Braberg, Robyn M. Kaake, Z. Zhang, Margaret Soucheray, Y. Zhou, Tia A. Tummino

, Michael McGregor, Matthew J. O’Meara, Ajda Rojc, Jyoti Batra

, Meghna Gupta, Zeynep Cakir, Matthew J. O'Meara

, Gwendolyn Jang, Jiewei Xu, Danielle L. Swaney, Helene Foussard, Manisha Ummadi, Dmitry Kuchenov, Merve Cakir

, Beril Tutuncuoglu, Ruth Huttenhain

, Ujjwal Rathore, Manon Eckhardt, Jacqueline M. Fabius, Ernst H. Pulido

, Zun Zar Chi Naing, Ying Shi, Rezelj Vv, Maya Modak, Paige Haas, Eirini Petsalaki, Kelsey M. Haas, Thomas Vallet, Danish Memon

, Alistair Dunham, Jesus A. Silvas

, Miguel Correa Marrero, Cassandra Koh, Yanxin Liu, Melody G. Campbell, Inigo Barrio-Hernandez

, Cristina Puchades, Michelle Moritz, Amy Diallo, Iris D. Young, Amber M. Smith, David Burke, Miles Sasha Dickinson, Henry C. Nguyen, Ursula Schulze-Gahmen, Devan Diwanji, Alexandrea N. Rizo, Caleigh M. Azumaya, Nadia Herrera, Carlos Nowotny, Christian Billesbolle, Ming Sun, Nick Hoppe, Gregory E. Merz, Axel F. Brilot, Huong T. Kratochvil, Gordon De, Un Seng Chio, Yen-Li Li, Jianhua Zhao, Junrui Li, Jen Chen, Cynthia M. Chio, Ishan Deshpande, Loan Doan, Phuong Nguyen, Bryan Faust, Daniel Asarnow, Sebastian Flores, Justin Biel, Mingliang Jin, Frank R. Moss, Kate Kim, Maliheh Safari, Alisa Bowen, Joana Paulino, Yang Zhang, Feng Wang, Victor L. Lam, Julian R. Braxton, Smriti Sangwan, Natalie Whitis, Paul V. Thomas, Fei Li, Aye C. Thwin, Kaitlin Schaefer, Komal Ishwar Pawar, Zanlin Yu, Thomas H. Pospiech, Raphael Trenker, Jessica K. Peters, Xi Liu, Kaihua Zhang, Megan Lo, Kyle E. Lopez, Arthur A. Melo, Eric Tse, Yang L. Li, Tsz Kin Martin Tsui, Fengbo Zhou, Daniel M. Williams, Daniel Saltzberg, Kris M. White, Amber S. Shun-Shion, Y. Li, Romel Rosales

, David Wu, Anthony J. Hodder, Arvind H. Patel, Albert Vallejo-Gracia, Suzannah Rihn, Lisa Miorin, Thomas Kehrer, Camille R. Simoneau, Sebastian Weigang, Theodore L. Roth, Mir M. Khalid, Y.-L. Li, Parinaz Fozouni, Abigail L. Lind, Elena Moreno

, Stuart Weston, Jisoo Park, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Maxime Chazal, Stuart G. Wilkinson, James Logue, Marisa McGrath, Francesco Berardi, Elaine Reid, Owens Tw, Robert Haupt, Matthew Elliott, Samantha Raggett, Mark Dorward, Rachel Toth, Clare Johnson, Fiona Brown, Anna Geyer, Kaake Rm, Daniel M. Giesel, Kerry A. Burness, C. James Hastie, Hannah Leech, Jennifer Oki, C. James Hastie, Nicola Goodman, Kathleen C. Keough, Katherine S. Pollard, Andrej Sali, Carla Baillie, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Kevin Holden, Daniel R. Southworth, Travis Maures, Robert M. Stroud, Yifan Cheng, James S. Fraser, Adam Frost, David A. Agard, Natalia Jura, Donovan Trinidad, Tanja Kortemme, Brian Shoichet, Aashish Manglik, Melanie Ott, Kevan M. Shokat, Massimo Palmarini, Paul Davies, Guo Jz, Matthew B. Frieman, Dario R. Alessi, Morgan Wirthlin, Trey Ideker, Jeremy A. Rassen, Huabin Zhao, Nolwenn Jouvenet, Kliment A. Verba, Carmen Abate, Georg Kochs, Oren S. Rosenberg, Corrie A. Painter, Adolfo Garcia-Sastre, Ola Wallerman, Marco Vignuzzi, Andrew A. Peden, Nicole S. Persky, Robert Grosse, Ross Swofford, Oliver A. Ryderq, Christopher F. Basler, Christian Billesbølle, Andreas R. Pfenning, Nevan J. Krogan, Pedro Beltrao, Krogan Nj, Emma C. Teeling, David A. Ray, Sarahjane Power, Martin T. Nweeia, Jureka As, Joana Damas, Graham M. Hughes, Marco Corbo, Bodgan Kirilenko, Michael Hiller, Klaus-Peter Koepfli, Irene Kaplow, Diane P. Genereux, Jennifer Meadows, Michael Dong, Shirley Xue Li, Vikki Marinescu, Kerstin Lindblad-Toh, Weckstein Ar, Gaurav Chauhan, Elinor K. Karlsson, Harris A. Lewin

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Abstract

How lethal coronaviruses engage hostsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordonet al.mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.Science, this issue p.eabe9403

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Abstract