Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Zhang, Ziyang; Zhou, Yuan; Zhou, Y.; Gordon, David E.; Hiatt, Joseph; Zhang, Z.; O’Meara, Matthew J.; Bouhaddou, Mehdi; Rezelj, Veronica Valentina; Ulferts, Svenja; Fabius, Jacqueline M.; Vv, Rezelj; Braberg, Hannes; Jureka, Alexander S.; Liu, Yanxin; Obernier, Kirsten; Campbell, Melody G.; Puchades, Cristina; Guo, Jeffrey Z.; Moritz, Michelle; Diallo, Amy; Young, Iris D.; Batra, Jyoti; Smith, Amber M.; Kaake, Robyn M.; Dickinson, Miles Sasha; Nguyen, Henry C.; Weckstein, Andrew R.; Shun-Shion, Amber S.; Schulze-Gahmen, Ursula; Owens, Tristan W.; Diwanji, Devan; Rizo, Alexandrea N.; Azumaya, Caleigh M.; Gupta, Meghna; Herrera, Nadia; Nowotny, Carlos; Pourmal, Sergei; Billesbolle, Christian; Sun, Ming; Hoppe, Nick; Titus, Erron W.; Merz, Gregory E.; Brilot, Axel F.; Kratochvil, Huong T.; Soucheray, Margaret; De, Gordon; Cakir, Merve; Chio, Un Seng; Li, Yen-Li; Zhao, Jianhua; Li, Junrui; McGregor, Michael; Chen, Jen; Chio, Cynthia M.; Deshpande, Ishan; Doan, Loan; Cakir, Zeynep; Nguyen, Phuong; Faust, Bryan; Asarnow, Daniel; Jang, Gwendolyn; Flores, Sebastian; Biel, Justin; Jin, Mingliang; O'Meara, Matthew J.; Moss, Frank R.; Tummino, Tia A.; Kim, Kate; Safari, Maliheh; Bowen, Alisa; Paulino, Joana; Zhang, Yang; Wang, Feng; Lam, Victor L.; Braxton, Julian R.; Sangwan, Smriti; Foussard, Helene; Whitis, Natalie; Rojc, Ajda; Thomas, Paul V.; Li, Fei; Thwin, Aye C.; Schaefer, Kaitlin; Pawar, Komal Ishwar; Yu, Zanlin; Pospiech, Thomas H.; Trenker, Raphael; Kuchenov, Dmitry; Peters, Jessica K.; Liu, Xi; Zhang, Kaihua; Lo, Megan; Lopez, Kyle E.; Huttenhain, Ruth; Xu, Jiewei; Melo, Arthur A.; Tse, Eric; Li, Yang L.; Tsui, Tsz Kin Martin; Zhou, Fengbo; Eckhardt, Manon; Williams, Daniel M.; Swaney, Danielle L.; Saltzberg, Daniel; White, Kris M.; Li, Y.; Rosales, Romel; Wu, David; Hodder, Anthony J.; Patel, Arvind H.; Ummadi, Manisha; Vallejo-Gracia, Albert; Rihn, Suzannah; Miorin, Lisa; Tutuncuoglu, Beril; Kehrer, Thomas; Simoneau, Camille R.; Weigang, Sebastian; Rathore, Ujjwal; Roth, Theodore L.; Khalid, Mir M.; Li, Y.-L.; Fozouni, Parinaz; Lind, Abigail L.; Modak, Maya; Moreno, Elena; Weston, Stuart; Park, Jisoo; Haas, Paige; Karim, Mohd Anisul; Ghoussaini, Maya; Dunham, Ian; Haas, Kelsey M.; Chazal, Maxime; Naing, Zun Zar Chi; Wilkinson, Stuart G.; Logue, James; McGrath, Marisa; Berardi, Francesco; Pulido, Ernst Heinz; Reid, Elaine; Tw, Owens; Haupt, Robert; Elliott, Matthew; Raggett, Samantha; Shi, Ying; Dorward, Mark; Toth, Rachel; Jm, Fabius; Johnson, Clare; Brown, Fiona; Geyer, Anna; Rm, Kaake; Giesel, Daniel M.; Barrio-Hernandez, Inigo; Burness, Kerry A.; Memon, Danish; Hastie, C. James; Leech, Hannah; Oki, Jennifer; Petsalaki, Eirini; James Hastie, C.; Goodman, Nicola; Keough, Kathleen C.; Pollard, Katherine S.; Sali, Andrej; Baillie, Carla; Dunham, Alistair; Klesh, Reyna J.; Hemphill, Kafi R.; Carlson-Stevermer, Jared; Holden, Kevin; Marrero, Miguel Correa; Southworth, Daniel R.; Maures, Travis; Stroud, Robert M.; Cheng, Yifan; Fraser, James S.; Frost, Adam; Agard, David A.; Jura, Natalia; Burke, David; Koh, Cassandra; Trinidad, Donovan; Kortemme, Tanja; Vallet, Thomas; Shoichet, Brian; Manglik, Aashish; Ott, Melanie; Shokat, Kevan M.; Palmarini, Massimo; Davies, Paul; Silvas, Jesus A.; Jz, Guo; Frieman, Matthew B.; Alessi, Dario R.; Wirthlin, Morgan; Ideker, Trey; Rassen, Jeremy A.; Zhao, Huabin; Jouvenet, Nolwenn; Verba, Kliment A.; Abate, Carmen; Kochs, Georg; Rosenberg, Oren S.; Painter, Corrie A.; Garcia-Sastre, Adolfo; Wallerman, Ola; Vignuzzi, Marco; Peden, Andrew A.; Persky, Nicole S.; Grosse, Robert; Swofford, Ross; Ryderq, Oliver A.; Basler, Christopher F.; Billesbølle, Christian; Pfenning, Andreas R.; Krogan, Nevan J.; Beltrao, Pedro; Nj, Krogan; Teeling, Emma C.; Ray, David A.; Power, Sarahjane; Nweeia, Martin T.; As, Jureka; Damas, Joana; Hughes, Graham M.; Corbo, Marco; Kirilenko, Bodgan; Hiller, Michael; Koepfli, Klaus-Peter; Kaplow, Irene; Genereux, Diane P.; Meadows, Jennifer; Dong, Michael; Li, Shirley Xue; Marinescu, Vikki; Lindblad-Toh, Kerstin; Ar, Weckstein; Chauhan, Gaurav; Karlsson, Elinor K.; Lewin, Harris A.

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David Gordon
Zhang et al., 2020

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American Association for the Advancement of Science, Science, 6521(370), 2020

DOI: 10.1126/science.abe9403

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@article{Zhang2020,
  abstract = {How lethal coronaviruses engage hostsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordonet al.mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.Science, this issue p.eabe9403},
  author = {Zhang, Ziyang and Zhou, Yuan and Zhou, Y. and Gordon, David E. and Hiatt, Joseph and Zhang, Z. and O’Meara, Matthew J. and Bouhaddou, Mehdi and Rezelj, Veronica Valentina and Ulferts, Svenja and Fabius, Jacqueline M. and Vv, Rezelj and Braberg, Hannes and Jureka, Alexander S. and Liu, Yanxin and Obernier, Kirsten and Campbell, Melody G. and Puchades, Cristina and Guo, Jeffrey Z. and Moritz, Michelle and Diallo, Amy and Young, Iris D. and Batra, Jyoti and Smith, Amber M. and Kaake, Robyn M. and Dickinson, Miles Sasha and Nguyen, Henry C. and Weckstein, Andrew R. and Shun-Shion, Amber S. and Schulze-Gahmen, Ursula and Owens, Tristan W. and Diwanji, Devan and Rizo, Alexandrea N. and Azumaya, Caleigh M. and Gupta, Meghna and Herrera, Nadia and Nowotny, Carlos and Pourmal, Sergei and Billesbolle, Christian and Sun, Ming and Hoppe, Nick and Titus, Erron W. and Merz, Gregory E. and Brilot, Axel F. and Kratochvil, Huong T. and Soucheray, Margaret and De, Gordon and Cakir, Merve and Chio, Un Seng and Li, Yen-Li and Zhao, Jianhua and Li, Junrui and McGregor, Michael and Chen, Jen and Chio, Cynthia M. and Deshpande, Ishan and Doan, Loan and Cakir, Zeynep and Nguyen, Phuong and Faust, Bryan and Asarnow, Daniel and Jang, Gwendolyn and Flores, Sebastian and Biel, Justin and Jin, Mingliang and O'Meara, Matthew J. and Moss, Frank R. and Tummino, Tia A. and Kim, Kate and Safari, Maliheh and Bowen, Alisa and Paulino, Joana and Zhang, Yang and Wang, Feng and Lam, Victor L. and Braxton, Julian R. and Sangwan, Smriti and Foussard, Helene and Whitis, Natalie and Rojc, Ajda and Thomas, Paul V. and Li, Fei and Thwin, Aye C. and Schaefer, Kaitlin and Pawar, Komal Ishwar and Yu, Zanlin and Pospiech, Thomas H. and Trenker, Raphael and Kuchenov, Dmitry and Peters, Jessica K. and Liu, Xi and Zhang, Kaihua and Lo, Megan and Lopez, Kyle E. and Huttenhain, Ruth and Xu, Jiewei and Melo, Arthur A. and Tse, Eric and Li, Yang L. and Tsui, Tsz Kin Martin and Zhou, Fengbo and Eckhardt, Manon and Williams, Daniel M. and Swaney, Danielle L. and Saltzberg, Daniel and White, Kris M. and Li, Y. and Rosales, Romel and Wu, David and Hodder, Anthony J. and Patel, Arvind H. and Ummadi, Manisha and Vallejo-Gracia, Albert and Rihn, Suzannah and Miorin, Lisa and Tutuncuoglu, Beril and Kehrer, Thomas and Simoneau, Camille R. and Weigang, Sebastian and Rathore, Ujjwal and Roth, Theodore L. and Khalid, Mir M. and Li, Y.-L. and Fozouni, Parinaz and Lind, Abigail L. and Modak, Maya and Moreno, Elena and Weston, Stuart and Park, Jisoo and Haas, Paige and Karim, Mohd Anisul and Ghoussaini, Maya and Dunham, Ian and Haas, Kelsey M. and Chazal, Maxime and Naing, Zun Zar Chi and Wilkinson, Stuart G. and Logue, James and McGrath, Marisa and Berardi, Francesco and Pulido, Ernst Heinz and Reid, Elaine and Tw, Owens and Haupt, Robert and Elliott, Matthew and Raggett, Samantha and Shi, Ying and Dorward, Mark and Toth, Rachel and Jm, Fabius and Johnson, Clare and Brown, Fiona and Geyer, Anna and Rm, Kaake and Giesel, Daniel M. and Barrio-Hernandez, Inigo and Burness, Kerry A. and Memon, Danish and Hastie, C. James and Leech, Hannah and Oki, Jennifer and Petsalaki, Eirini and James Hastie, C. and Goodman, Nicola and Keough, Kathleen C. and Pollard, Katherine S. and Sali, Andrej and Baillie, Carla and Dunham, Alistair and Klesh, Reyna J. and Hemphill, Kafi R. and Carlson-Stevermer, Jared and Holden, Kevin and Marrero, Miguel Correa and Southworth, Daniel R. and Maures, Travis and Stroud, Robert M. and Cheng, Yifan and Fraser, James S. and Frost, Adam and Agard, David A. and Jura, Natalia and Burke, David and Koh, Cassandra and Trinidad, Donovan and Kortemme, Tanja and Vallet, Thomas and Shoichet, Brian and Manglik, Aashish and Ott, Melanie and Shokat, Kevan M. and Palmarini, Massimo and Davies, Paul and Silvas, Jesus A. and Jz, Guo and Frieman, Matthew B. and Alessi, Dario R. and Wirthlin, Morgan and Ideker, Trey and Rassen, Jeremy A. and Zhao, Huabin and Jouvenet, Nolwenn and Verba, Kliment A. and Abate, Carmen and Kochs, Georg and Rosenberg, Oren S. and Painter, Corrie A. and Garcia-Sastre, Adolfo and Wallerman, Ola and Vignuzzi, Marco and Peden, Andrew A. and Persky, Nicole S. and Grosse, Robert and Swofford, Ross and Ryderq, Oliver A. and Basler, Christopher F. and Billesbølle, Christian and Pfenning, Andreas R. and Krogan, Nevan J. and Beltrao, Pedro and Nj, Krogan and Teeling, Emma C. and Ray, David A. and Power, Sarahjane and Nweeia, Martin T. and As, Jureka and Damas, Joana and Hughes, Graham M. and Corbo, Marco and Kirilenko, Bodgan and Hiller, Michael and Koepfli, Klaus-Peter and Kaplow, Irene and Genereux, Diane P. and Meadows, Jennifer and Dong, Michael and Li, Shirley Xue and Marinescu, Vikki and Lindblad-Toh, Kerstin and Ar, Weckstein and Chauhan, Gaurav and Karlsson, Elinor K. and Lewin, Harris A.},
  doi = {10.1126/science.abe9403},
  journal = {Science},
  month = {oct},
  title = {Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.},
  url = {https://oadoi.org/10.1126/science.abe9403},
  volume = {370},
  year = {2020}
}

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

Journal article published in 2020 by Ziyang Zhang, Yuan Zhou, Y. Zhou, David E. Gordon

, Joseph Hiatt, Z. Zhang, Matthew J. O’Meara, Mehdi Bouhaddou, Veronica Valentina Rezelj, Svenja Ulferts, Jacqueline M. Fabius, Rezelj Vv, Hannes Braberg, Alexander S. Jureka, Yanxin Liu and other authors. Ziyang Zhang, Yuan Zhou, Y. Zhou, David E. Gordon

, Joseph Hiatt, Z. Zhang, Matthew J. O’Meara, Mehdi Bouhaddou, Veronica Valentina Rezelj, Svenja Ulferts, Jacqueline M. Fabius, Rezelj Vv, Hannes Braberg, Alexander S. Jureka, Yanxin Liu, Kirsten Obernier, Melody G. Campbell, Cristina Puchades, Jeffrey Z. Guo, Michelle Moritz, Amy Diallo, Iris D. Young, Jyoti Batra

, Amber M. Smith, Robyn M. Kaake, Miles Sasha Dickinson, Henry C. Nguyen, Andrew R. Weckstein, Amber S. Shun-Shion

, Ursula Schulze-Gahmen, Tristan W. Owens, Devan Diwanji, Alexandrea N. Rizo, Caleigh M. Azumaya, Meghna Gupta, Nadia Herrera, Carlos Nowotny, Sergei Pourmal, Christian Billesbolle, Ming Sun, Nick Hoppe, Erron W. Titus, Gregory E. Merz, Axel F. Brilot, Huong T. Kratochvil, Margaret Soucheray, Gordon De, Merve Cakir

, Un Seng Chio, Yen-Li Li, Jianhua Zhao, Junrui Li, Michael McGregor, Jen Chen, Cynthia M. Chio, Ishan Deshpande, Loan Doan, Zeynep Cakir, Phuong Nguyen, Bryan Faust, Daniel Asarnow, Gwendolyn Jang, Sebastian Flores, Justin Biel, Mingliang Jin, Matthew J. O'Meara

, Frank R. Moss, Tia A. Tummino

, Kate Kim, Maliheh Safari, Alisa Bowen, Joana Paulino, Yang Zhang, Feng Wang, Victor L. Lam, Julian R. Braxton, Smriti Sangwan, Helene Foussard, Natalie Whitis, Ajda Rojc, Paul V. Thomas, Fei Li, Aye C. Thwin, Kaitlin Schaefer, Komal Ishwar Pawar, Zanlin Yu, Thomas H. Pospiech, Raphael Trenker, Dmitry Kuchenov, Jessica K. Peters, Xi Liu, Kaihua Zhang, Megan Lo, Kyle E. Lopez, Ruth Huttenhain

, Jiewei Xu, Arthur A. Melo, Eric Tse, Yang L. Li, Tsz Kin Martin Tsui, Fengbo Zhou, Manon Eckhardt, Daniel M. Williams, Danielle L. Swaney, Daniel Saltzberg, Kris M. White, Y. Li, Romel Rosales

, David Wu, Anthony J. Hodder, Arvind H. Patel, Manisha Ummadi, Albert Vallejo-Gracia, Suzannah Rihn, Lisa Miorin, Beril Tutuncuoglu, Thomas Kehrer, Camille R. Simoneau, Sebastian Weigang, Ujjwal Rathore, Theodore L. Roth, Mir M. Khalid, Y.-L. Li, Parinaz Fozouni, Abigail L. Lind, Maya Modak, Elena Moreno

, Stuart Weston, Jisoo Park, Paige Haas, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Kelsey M. Haas

, Maxime Chazal, Zun Zar Chi Naing, Stuart G. Wilkinson, James Logue, Marisa McGrath, Francesco Berardi, Ernst Heinz Pulido

, Elaine Reid, Owens Tw, Robert Haupt, Matthew Elliott, Samantha Raggett, Ying Shi, Mark Dorward, Rachel Toth, Fabius Jm, Clare Johnson, Fiona Brown, Anna Geyer, Kaake Rm, Daniel M. Giesel, Inigo Barrio-Hernandez

, Kerry A. Burness, Danish Memon

, C. James Hastie, Hannah Leech, Jennifer Oki, Eirini Petsalaki, C. James Hastie, Nicola Goodman, Kathleen C. Keough, Katherine S. Pollard, Andrej Sali, Carla Baillie, Alistair Dunham, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Kevin Holden, Miguel Correa Marrero, Daniel R. Southworth, Travis Maures, Robert M. Stroud, Yifan Cheng, James S. Fraser, Adam Frost, David A. Agard, Natalia Jura, David Burke, Cassandra Koh, Donovan Trinidad, Tanja Kortemme, Thomas Vallet, Brian Shoichet, Aashish Manglik, Melanie Ott, Kevan M. Shokat, Massimo Palmarini, Paul Davies, Jesus A. Silvas

, Guo Jz, Matthew B. Frieman, Dario R. Alessi, Morgan Wirthlin, Trey Ideker, Jeremy A. Rassen, Huabin Zhao, Nolwenn Jouvenet, Kliment A. Verba, Carmen Abate, Georg Kochs, Oren S. Rosenberg, Corrie A. Painter, Adolfo Garcia-Sastre, Ola Wallerman, Marco Vignuzzi, Andrew A. Peden, Nicole S. Persky, Robert Grosse, Ross Swofford, Oliver A. Ryderq, Christopher F. Basler, Christian Billesbølle, Andreas R. Pfenning, Nevan J. Krogan, Pedro Beltrao, Krogan Nj, Emma C. Teeling, David A. Ray, Sarahjane Power, Martin T. Nweeia, Jureka As, Joana Damas, Graham M. Hughes, Marco Corbo, Bodgan Kirilenko, Michael Hiller, Klaus-Peter Koepfli, Irene Kaplow, Diane P. Genereux, Jennifer Meadows, Michael Dong, Shirley Xue Li, Vikki Marinescu, Kerstin Lindblad-Toh, Weckstein Ar, Gaurav Chauhan, Elinor K. Karlsson, Harris A. Lewin

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Abstract

How lethal coronaviruses engage hostsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordonet al.mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.Science, this issue p.eabe9403

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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

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