The study aimed to verify the discriminant capacity of the factors of the Clinical Dimensional Personality Inventory 2 (IDCP-2) in the identification of people with substance dependence, as well as to compare this capacity with another instrument that evaluates pathological traits, the Personality Inventory for DSM-5 (PID-5). The sample was composed of 253 adults distributed in three groups: community sample, represented by 110 individuals with ages between 20 and 66 years (M = 32.3; SD = 10,1), 71.8% women; subclinical, 119 individual aged from 18 to 63 (M = 30.4; SD = 8.34), 61.3% women; clinical, 24 individual with ages between 19 and 59 (M = 36,4; SD = 11.2), 83.3% men. Two scales for substance dependence identification were administered (AUDIT and ASSIST), IDCP-2, and PID-5. Findings indicated that IDCP-2 is capable of discriminating between groups, mainly the extreme ones (i.e., clinical sample versus community sample). Moreover, similar discriminant capacity between IDCP-2 and PID-5 was observed. These findings are preliminary evidence that the IDCP-2 factors can identify people with substance dependence, with Hopelessness being the leading factor in the assessment of substance dependents.