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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 3(65), 2021

DOI: 10.1128/aac.02143-20

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Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum

Journal article published in 2020 by Heather J. Painter ORCID, Joanne M. Morrisey, Michael W. Mather ORCID, Lindsey M. Orchard ORCID, Cuyler Luck ORCID, Martin J. Smilkstein ORCID, Michael K. Riscoe ORCID, Akhil B. Vaidya ORCID, Manuel Llinás ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The continued emergence of drug-resistant Plasmodium falciparum parasites hinders global attempts to eradicate malaria, emphasizing the need to identify new antimalarial drugs. Attractive targets for chemotherapeutic intervention are the cytochrome (cyt) bc 1 complex, which is an essential component of the mitochondrial electron transport chain (mtETC) required for ubiquinone recycling and mitochondrially localized dihydroorotate dehydrogenase (DHODH) critical for de novo pyrimidine synthesis.