This study aims to calculate the combined and individual effects of the optical thickness of aerosols (AOT) and precipitable water vapour (PWV) on the solar radiation reaching the Earth’s surface at a global scale and to analyse its spatial and temporal variation. For that purpose, a novel but validated methodology is applied to CERES SYN1deg products for the period 2000–2019. Spatial distributions of AOT and PWV effects, both individually and combined, show a close link with the spatial distributions of AOT and PWV. The spatially averaged combined effect results in a −13.9% reduction in irradiance, while the average AOT effect is −2.3%, and the PWV effect is −12.1%. The temporal analysis focuses on detecting trends in the anomalies. The results show overall positive trends for AOT and PWV. Consequently, significant negative overall trends are found for the effects. However, significant positive trends for the individual AOT and the combined AOT-PWV effects are found in specific regions, such as the eastern United States, Europe or Asia, indicating successful emission control policies in these areas. This study contributes to a better understanding of the individual and combined effects of aerosols and water vapour on solar radiation at a global scale.