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American Association for the Advancement of Science, Science Advances, 7(7), 2021

DOI: 10.1126/sciadv.abd7954

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Prostaglandin E <sub>2</sub> promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells

Journal article published in 2021 by Siobhan Crittenden ORCID, Marie Goepp ORCID, Jolinda Pollock ORCID, Calum T. Robb ORCID, Danielle J. Smyth ORCID, You Zhou ORCID, Robert Andrews ORCID, Victoria Tyrrell ORCID, Konstantinos Gkikas ORCID, Alexander Adima ORCID, Richard A. O’Connor ORCID, Luke Davies, Xue-Feng Li, Hatti X. Yao, Gwo-Tzer Ho and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

PGE 2 inhibits T regs and promotes intestinal inflammation through actions on mononuclear phagocytes and the gut microbiota.