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American Society for Microbiology, Journal of Virology, 9(95), 2021

DOI: 10.1128/jvi.02422-20

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The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2

Journal article published in 2021 by Helena Winstone, Maria Jose Lista, Alisha C. Reid, Clement Bouton, Suzy Pickering, Rui Pedro Galao ORCID, Claire Kerridge, Katie J. Doores, Chad M. Swanson ORCID, Stuart J. D. Neil ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The furin cleavage site in the spike protein is a distinguishing feature of SARS-CoV-2 and has been proposed to be a determinant for the higher transmissibility between individuals, compared to SARS-CoV-1. One explanation for this is that it permits more efficient activation of fusion at or near the cell surface rather than requiring processing in the endosome of the target cell.