Published in
American Society for Microbiology, Journal of Virology, 9(95), 2021
DOI: 10.1128/jvi.02422-20
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The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2
Journal article published in 2021 by
Helena Winstone,
Maria Jose Lista,
Alisha C. Reid,
Clement Bouton,
Suzy Pickering,
Rui Pedro Galao 
,
Claire Kerridge,
Katie J. Doores,
Chad M. Swanson ,
Stuart J. D. Neil
,
Claire Kerridge,
Katie J. Doores,
Chad M. Swanson ,
Stuart J. D. Neil
This paper is made freely available by the publisher.
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Abstract
The furin cleavage site in the spike protein is a distinguishing feature of SARS-CoV-2 and has been proposed to be a determinant for the higher transmissibility between individuals, compared to SARS-CoV-1. One explanation for this is that it permits more efficient activation of fusion at or near the cell surface rather than requiring processing in the endosome of the target cell.