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American Society for Microbiology, Journal of Clinical Microbiology, 4(59), 2021

DOI: 10.1128/jcm.02328-20

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On the consequences of poorly defined breakpoints for rifampin susceptibility testing of Mycobacterium tuberculosis complex

Journal article published in 2021 by Claudio U. Köser ORCID, Sophia B. Georghiou ORCID, Thomas Schön, Max Salfinger
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In a recent report of a systematic review of critical concentrations (CCs), the World Health Organization (WHO) lowered the rifampin (RIF) CC for antimicrobial susceptibility testing (AST) of the Mycobacterium tuberculosis complex using Middlebrook 7H10 medium and the Bactec mycobacterial growth indicator tube (MGIT) 960 system from 1 to 0.5 μg/ml. The previous RIF CC for 7H10 had been in use for over half a century.