Published in
American Physiological Society, AJP - Endocrinology and Metabolism, 4(320), p. E680-E690, 2021
DOI: 10.1152/ajpendo.00275.2020
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MOTS-c reduces myostatin and muscle atrophy signaling
Journal article published in 2021 by
Hiroshi Kumagai,
Ana Raquel Coelho,
Junxiang Wan,
Hemal H. Mehta,
Kelvin Yen 
,
Amy Huang,
Hirofumi Zempo,
Noriyuki Fuku,
Seiji Maeda ,
Paulo J. Oliveira,
Pinchas Cohen,
Su-Jeong Kim
,
Amy Huang,
Hirofumi Zempo,
Noriyuki Fuku,
Seiji Maeda ,
Paulo J. Oliveira,
Pinchas Cohen,
Su-Jeong Kim
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Abstract
MOTS-c, a mitochondrial-derived peptide reduces high-fat-diet-induced muscle atrophy signaling by reducing myostatin expression. The CK2-PTEN-mTORC2-AKT-FOXO1 pathways play key roles in MOTS-c action on myostatin expression.