Published in
American Association for the Advancement of Science, Science Translational Medicine, 580(13), 2021
DOI: 10.1126/scitranslmed.aau8491
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Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis
Journal article published in 2021 by
Elijah L. Carlson 
,
Vengadeshprabhu Karuppagounder,
William J. Pinamont ,
Natalie K. Yoshioka ,
Adeel Ahmad ,
Eric M. Schott ,
Heather K. Le Bleu ,
Michael J. Zuscik ,
Reyad A. Elbarbary,
Fadia Kamal
,
Vengadeshprabhu Karuppagounder,
William J. Pinamont ,
Natalie K. Yoshioka ,
Adeel Ahmad ,
Eric M. Schott ,
Heather K. Le Bleu ,
Michael J. Zuscik ,
Reyad A. Elbarbary,
Fadia Kamal
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Abstract
G protein–coupled receptor kinase 2 is increased in OA, and inhibition by the antidepressant paroxetine prevents disease progression.