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American Society for Microbiology, mBio, 1(12), 2021

DOI: 10.1128/mbio.03193-20

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(p)ppGpp/GTP and Malonyl-CoA Modulate Staphylococcus aureus Adaptation to FASII Antibiotics and Provide a Basis for Synergistic Bi-Therapy

Journal article published in 2021 by Amit Pathania, Jamila Anba-Mondoloni, Myriam Gominet, David Halpern, Julien Dairou ORCID, Laëtitia Dupont, Gilles Lamberet, Patrick Trieu-Cuot, Karine Gloux, Alexandra Gruss
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Staphylococcus aureus is a major human bacterial pathogen for which new inhibitors are urgently needed. Antibiotic development has centered on the fatty acid synthesis (FASII) pathway, which provides the building blocks for bacterial membrane phospholipids.