A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA
Journal article published in 2021 by
Zhenyao Luo,
Jacqueline R. Morey,
Evelyne Deplazes 
,
Alina Motygullina,
Aimee Tan ,
Katherine Ganio ,
Stephanie L. Neville ,
Nikolaos Eleftheriadis ,
Michael Isselstein,
Victoria G. Pederick,
James C. Paton ,
Thorben Cordes ,
Jeffrey R. Harmer,
Bostjan Kobe ,
Christopher A. McDevitt
,
Alina Motygullina,
Aimee Tan ,
Katherine Ganio ,
Stephanie L. Neville ,
Nikolaos Eleftheriadis ,
Michael Isselstein,
Victoria G. Pederick,
James C. Paton ,
Thorben Cordes ,
Jeffrey R. Harmer,
Bostjan Kobe ,
Christopher A. McDevitt
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Zinc is an essential nutrient for the virulence of bacterial pathogens such as Streptococcus pneumoniae . Many Gram-positive bacteria use a two-domain lipoprotein for zinc acquisition, but how this class of metal-recruiting proteins acquire zinc and interact with the uptake machinery has remained poorly defined.