Abstract This Perspective presents comments intended for junior researchers by Carol A. Lange, Editor-in-Chief, Endocrinology, and Stephen R. Hammes, former Editor-in-Chief, Molecular Endocrinology, and former co-Editor-in-Chief, Endocrinology. Principal points 1. Know when you are ready and identify your target audience. 2. Select an appropriate journal. 3. Craft your title and abstract to capture your key words and deliver your message. 4. Tell a clear and impactful story. 5. Review, polish, and perfect your manuscript.