Published in
Royal Society of Chemistry, Chemical Science, 11(12), p. 3876-3884, 2021
DOI: 10.1039/d0sc05411a
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Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites
Journal article published in 2021 by
Xue Zhi Zhao 
,
Evgeny Kiselev,
George T. Lountos ,
Wenjie Wang,
Joseph E. Tropea,
Danielle Needle,
Thomas A. Hilimire,
John S. Schneekloth ,
David S. Waugh,
Yves Pommier,
Terrence R. Burke
,
Evgeny Kiselev,
George T. Lountos ,
Wenjie Wang,
Joseph E. Tropea,
Danielle Needle,
Thomas A. Hilimire,
John S. Schneekloth ,
David S. Waugh,
Yves Pommier,
Terrence R. Burke
This paper is made freely available by the publisher.
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Abstract
Using small molecule microarray TDP1 inhibitors have been identified that bind in a trivalent mode.