Published in
American Association for the Advancement of Science, Science Advances, 5(7), 2021
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Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
Journal article published in 2021 by
Mattia Deluigi 
,
Alexander Klipp ,
Christoph Klenk ,
Lisa Merklinger ,
Stefanie A. Eberle ,
Lena Morstein ,
Philipp Heine ,
Peer R. E. Mittl,
Patrick Ernst ,
Theodore M. Kamenecka,
Yuanjun He ,
Santiago Vacca ,
Pascal Egloff,
Annemarie Honegger ,
Andreas Plückthun
,
Alexander Klipp ,
Christoph Klenk ,
Lisa Merklinger ,
Stefanie A. Eberle ,
Lena Morstein ,
Philipp Heine ,
Peer R. E. Mittl,
Patrick Ernst ,
Theodore M. Kamenecka,
Yuanjun He ,
Santiago Vacca ,
Pascal Egloff,
Annemarie Honegger ,
Andreas Plückthun
This paper is made freely available by the publisher.
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Abstract
Crystal structures of NTSR1 bound to agonists, inverse agonists, and in the apo state enabled by a novel fusion to DARPin D12.