The upper layer of Oil field A is developed by horizontal linear well pattern with long well segment. After completion, there is relatively serious formation damage, and the tested epidermal factor is up to 6.21 on average. Due to the length of horizontal well section and the serious vertical heterogeneity of formation, some strata were over-acidized in the early stage, so it was very difficult to distribute acid evenly. For this reason, the low contribution layer of horizontal section was determined by using amino carboxylic acid system and coiled tubing hydrojet acidification process, combined with reservoir characteristics, and the spindle-type acid distribution method was adopted to optimize nozzle combination parameters to predict construction displacement and ground construction pressure. The laboratory experiment was carried out to compare with the conventional acid system for core displacement experiment. The acid could form acid-etch wormhole, effectively extend the acid-action distance, and achieve the purpose of slow and deep penetration.