Based on Fluent software, a mathematical model of thermosyphon pump is established and numerical simulation is carried out to study the influence of riser tube length, tube diameter and immersion ratio on liquid lifting capacity and efficiency. The results showed that: the liquid lifting volume increased with the increase of immersion ratio, whereas the lifting efficiency showed a trend of increasing followed by decreasing. The highest lifting efficiency for a 340mm long, 6mm diameter riser achieved when the immersion ratio is 0.35. With the increasing of the height in riser, the velocity of the gas phase close to the wall in the thermosyphon pump was higher than the velocity along the radial direction. In order to enhance fluid interchange, corners of the refrigeration box were designed to be arc-shaped with a higher corner speed and lower temperature.