Published in
American Association for the Advancement of Science, Science Immunology, 55(6), 2021
DOI: 10.1126/sciimmunol.abe4782
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Severely ill patients with COVID-19 display impaired exhaustion features in SARS-CoV-2–reactive CD8 <sup>+</sup> T cells
Journal article published in 2021 by
Anthony Kusnadi 
,
Ciro Ramírez-Suástegui ,
Vicente Fajardo ,
Serena J. Chee ,
Benjamin J. Meckiff ,
Hayley Simon,
Emanuela Pelosi,
Grégory Seumois ,
Ferhat Ay ,
Pandurangan Vijayanand ,
Christian H. Ottensmeier
,
Ciro Ramírez-Suástegui ,
Vicente Fajardo ,
Serena J. Chee ,
Benjamin J. Meckiff ,
Hayley Simon,
Emanuela Pelosi,
Grégory Seumois ,
Ferhat Ay ,
Pandurangan Vijayanand ,
Christian H. Ottensmeier
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Abstract
Fewer SARS-CoV-2–reactive memory CD8 + T cells with “exhaustion” features are present in patients with severe versus mild COVID-19.