Published in
American Society for Microbiology, mSystems, 1(6), 2021
DOI: 10.1128/msystems.00981-20
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Pangenome Analytics Reveal Two-Component Systems as Conserved Targets in ESKAPEE Pathogens
Journal article published in 2021 by
Akanksha Rajput 
,
Yara Seif ,
Kumari Sonal Choudhary ,
Christopher Dalldorf,
Saugat Poudel ,
Jonathan M. Monk ,
Bernhard O. Palsson
,
Yara Seif ,
Kumari Sonal Choudhary ,
Christopher Dalldorf,
Saugat Poudel ,
Jonathan M. Monk ,
Bernhard O. Palsson
This paper is made freely available by the publisher.
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Abstract
The ESKAPEE pathogens are the leading cause of health care-associated infections worldwide. Two-component systems (TCSs) can be used as effective targets against pathogenic bacteria since they are ubiquitous and manage various vital functions such as antibiotic resistance, virulence, biofilms, quorum sensing, and pH balance, among others.