Significance Accumulation of nanopollutants in lifeforms has become the subject of increasing concern, but effects are not understood. Biological systems are inherently complex, and therefore any small variations on the membrane properties can potentially perturb cell functionality. In this study we observe that the presence of styrene oligomers in lipid membranes alters their phase behavior, with stronger changes occurring in more complex systems, which could translate into potential cellular disruption. This study provides evidence that the presence of nanopollutants in the membrane may alter its fundamental properties and affect cell viability.