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American Society for Microbiology, mSphere, 1(6), 2021

DOI: 10.1128/msphere.01216-20

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Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Journal article published in 2021 by Juliette L. Oakley, Rebecca Weiser, Lydia C. Powell ORCID, Julian Forton, Eshwar Mahenthiralingam ORCID, Philip D. Rye, Katja E. Hill ORCID, David W. Thomas, Manon F. Pritchard ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The emergence of multidrug-resistant (MDR) pathogens within biofilms in the cystic fibrosis lung results in increased morbidity. An inhalation therapy derived from alginate, OligoG CF-5/20, is currently in clinical trials for cystic fibrosis patients.