Published in
American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 3(320), p. H1055-H1065, 2021
DOI: 10.1152/ajpheart.00651.2020
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Pannexin 1 Channels Control the Hemodynamic Response to Hypoxia by Regulating O2-Sensitive Extracellular ATP in Blood
Journal article published in 2021 by
Brett S. Kirby 
,
Matthew A. Sparks ,
Eduardo R. Lazarowski ,
Denise A. Lopez Domowicz,
Hongmei Zhu,
Timothy J. McMahon
,
Matthew A. Sparks ,
Eduardo R. Lazarowski ,
Denise A. Lopez Domowicz,
Hongmei Zhu,
Timothy J. McMahon
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Abstract
Export of vasodilator ATP from red blood cells requires pannexin 1. Blood plasma ATP elevations in response to hypoxia in mice require pannexin 1. Hemodynamic responses to hypoxia are accompanied by increased plasma ATP in mice in vivo and require pannexin 1.