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American Association for the Advancement of Science, Science Advances, 3(7), 2021

DOI: 10.1126/sciadv.abd4484

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Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Journal article published in 2021 by Yi-Chuan Li ORCID, Ti-Chun Chao ORCID, Hee Jong Kim ORCID, Timothy Cholko ORCID, Shin-Fu Chen ORCID, Guojie Li ORCID, Laura Snyder, Kotaro Nakanishi ORCID, Chia-En Chang ORCID, Kenji Murakami ORCID, Benjamin A. Garcia, Thomas G. Boyer ORCID, Kuang-Lei Tsai ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The structure of Mediator kinase module reveals its Med12-dependent Cdk8 activation mechanism and an Argonaute-like Med13 protein.