Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 4(65), 2021
DOI: 10.1128/aac.01757-20
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Structural and biochemical characterization of the novel CTX-M-151 extended-spectrum β-lactamase and its inhibition by Avibactam
Journal article published in 2021 by
Barbara Ghiglione,
María Margarita Rodríguez,
Florencia Brunetti,
Krisztina M. Papp-Wallace 
,
Ayumi Yoshizumi,
Yoshikazu Ishii,
Robert A. Bonomo ,
Gabriel Gutkind,
Sebastián Klinke ,
Pablo Power
,
Ayumi Yoshizumi,
Yoshikazu Ishii,
Robert A. Bonomo ,
Gabriel Gutkind,
Sebastián Klinke ,
Pablo Power
This paper is made freely available by the publisher.
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Abstract
The diazabicyclooctane (DBO) inhibitor avibactam (AVI) reversibly inactivates most serine β-lactamases, including the CTX-M β-lactamases. Currently, more than 230 unique CTX-M members distributed in five clusters with less than 5% amino acid sequence divergence within each group have been described.