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American Physiological Society, AJP - Endocrinology and Metabolism, 3(320), p. E496-E511, 2021

DOI: 10.1152/ajpendo.00346.2020

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Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis

Journal article published in 2021 by Encarnacion Torres, Inmaculada Velasco, Manuel Tena-Sempere ORCID, Delphine Franssen, Violeta Heras, Francisco Gaytan, Silvia Leon, Victor M. Navarro, Rafael Pineda, M. Luz Candenas, Antonio Romero-Ruiz ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We have explored here the impact of congenital ablation of the gene ( Tacr2) encoding the tachykinin receptor, NK2R, in terms of neuroendocrine control of the reproductive axis, using a novel Tacr2 KO mouse line. Our data support a modest, albeit detectable, role of NK2R in the control of the gonadotropic axis, with partially overlapping and redundant functions with other tachykinin receptors.