The new standards on energy saving for new and existing buildings have animated both researchers and technicians in recent years, aiming at reducing the dependence on fossil fuels, improving indoor comfort, and systems efficiency. In this scenario, special attention must be paid to historical buildings that need to preserve their key testimonial heritage within the society. This paper describes the design and realization stages of a pilot system based on a ground-coupled heat pump, operating both in heating and cooling modes, installed in the monumental site of Saints Marcellino and Festo (SM&F), in Naples, Southern Italy. This study aims to demonstrate that low-enthalpy geothermal systems can be employed as energy retrofit applications in buildings of historical, artistic, and cultural interest and, at the same time, to prove that the use of this technology allows achieving the objectives, set at global level by the current regulations, and requiring a reduction of carbon dioxide emissions (tCO2) of 53% compared to technology using fossil fuels.