Background: SARS-COV-2 causes the highly pathogenic disease called COVID-19. This disease leads to varieties of respiratory infections like pneumonia, cold, sneezing, etc. As this disease is being transmitted via airborne droplets, it is highly essential to use PPEs including masks, gloves, etc. This virus interacts with ACE2 receptor and further makes its entry into host cells leading viral pathogenesis. This viral is reported to be originated from Wuhan market, China. Despite of on-going efforts to control the spread, numbers of cases of COVID-19 are increasing on daily basis. Objective: This study aims to collect more information about aspects of nanotechnology based applications towards COVID-19 management. Methods: A systemic search has been carried out using PubMed, Google Scholar, CNKI, etc. for relevant studies. Results and Conclusions: Nanotechnology based various approaches like nanomedicines, surface coatings with nanoparticles, nanoparticle coated PPEs, and nanosensors could significantly reduce the healthcare burden by reducing the spread. Current review focuses on various approaches of nanotechnology during the pandemic COVID-19.